Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC5799801 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Yang Xi X Fu Yinjia Y Hu Fuqing F Luo Xuelai X Hu Junbo J Wang Guihua G
Experimental & molecular medicine 20180119 1
Phosphatidylinositol 3-kinase (PI3K) signaling plays an important role in the regulation of cellular lipid metabolism and non-alcoholic fatty liver disease (NAFLD). However, little is known about the role of the regulatory subunits of PI3K in lipid metabolism and NAFLD. In this study, we characterized the functional role of PIK3R3 in fasting-induced hepatic lipid metabolism. In this study, we showed that the overexpression of PIK3R3 promoted hepatic fatty acid oxidation via PIK3R3-induced expres ...[more]