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Cobalt catalyzed sp3 C-H amination utilizing aryl azides.

ABSTRACT: A dinuclear Co(ii) complex supported by a modular, tunable redox-active ligand system is capable of selective C-H amination to form indolines from aryl azides in good yields at low (1 mol%) catalyst loading. The reaction is tolerant of medicinally relevant heterocycles, such as pyridine and indole, and can be used to form 5-, 6-, and 7-membered rings. The synthetic versatility obtained using low loadings of an earth abundant transition metal complex represents a significant advance in catalytic C-H amination technology.

SUBMITTER: Villanueva O

PROVIDER: S-EPMC5802275 | biostudies-other | 2015 Nov

REPOSITORIES: biostudies-other

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Cobalt catalyzed sp<sup>3</sup> C-H amination utilizing aryl azides.

Villanueva Omar O Weldy Nina Mace NM Blakey Simon B SB MacBeth Cora E CE

Chemical science 20150730 11

A dinuclear Co(ii) complex supported by a modular, tunable redox-active ligand system is capable of selective C-H amination to form indolines from aryl azides in good yields at low (1 mol%) catalyst loading. The reaction is tolerant of medicinally relevant heterocycles, such as pyridine and indole, and can be used to form 5-, 6-, and 7-membered rings. The synthetic versatility obtained using low loadings of an earth abundant transition metal complex represents a significant advance in catalytic ...[more]

PMID: 29435216

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