Huntingtin gene repeat size variations affect risk of lifetime depression.
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ABSTRACT:
SUBMITTER: Gardiner SL
PROVIDER: S-EPMC5802693 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
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Huntingtin gene repeat size variations affect risk of lifetime depression.
Gardiner Sarah L SL van Belzen Martine J MJ Boogaard Merel W MW van Roon-Mom Willeke M C WMC Rozing Maarten P MP van Hemert Albert M AM Smit Johannes H JH Beekman Aartjan T F ATF van Grootheest Gerard G Schoevers Robert A RA Oude Voshaar Richard C RC Roos Raymund A C RAC Comijs Hannie C HC Penninx Brenda W J H BWJH van der Mast Roos C RC Aziz N Ahmad NA
Translational psychiatry 20171211 12
Huntington disease (HD) is a severe neuropsychiatric disorder caused by a cytosine-adenine-guanine (CAG) repeat expansion in the HTT gene. Although HD is frequently complicated by depression, it is still unknown to what extent common HTT CAG repeat size variations in the normal range could affect depression risk in the general population. Using binary logistic regression, we assessed the association between HTT CAG repeat size and depression risk in two well-characterized Dutch cohorts─the Nethe ...[more]
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