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Huntingtin gene repeat size variations affect risk of lifetime depression.

ABSTRACT: Huntington disease (HD) is a severe neuropsychiatric disorder caused by a cytosine-adenine-guanine (CAG) repeat expansion in the HTT gene. Although HD is frequently complicated by depression, it is still unknown to what extent common HTT CAG repeat size variations in the normal range could affect depression risk in the general population. Using binary logistic regression, we assessed the association between HTT CAG repeat size and depression risk in two well-characterized Dutch cohorts?the Netherlands Study of Depression and Anxiety and the Netherlands Study of Depression in Older Persons?including 2165 depressed and 1058 non-depressed persons. In both cohorts, separately as well as combined, there was a significant non-linear association between the risk of lifetime depression and HTT CAG repeat size in which both relatively short and relatively large alleles were associated with an increased risk of depression (??=?-0.292 and ??=?0.006 for the linear and the quadratic term, respectively; both P?

SUBMITTER: Gardiner SL 

PROVIDER: S-EPMC5802693 | biostudies-other | 2017 Dec

REPOSITORIES: biostudies-other

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Huntington disease (HD) is a severe neuropsychiatric disorder caused by a cytosine-adenine-guanine (CAG) repeat expansion in the HTT gene. Although HD is frequently complicated by depression, it is still unknown to what extent common HTT CAG repeat size variations in the normal range could affect depression risk in the general population. Using binary logistic regression, we assessed the association between HTT CAG repeat size and depression risk in two well-characterized Dutch cohorts─the Nethe  ...[more]