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Plasma homocysteine concentrations and risk of intracerebral hemorrhage: a systematic review and meta-analysis.


ABSTRACT: Intracerebral hemorrhage (ICH) has the highest mortality rate in all strokes. However, controversy still exists concerning the association between plasma homocysteine (Hcy) and ICH. A systematic review and meta-analysis was conducted using Pubmed, Embase, and Web of Science up to April 18, 2017. Standard mean difference (SMD) for mean differences of plasma Hcy levels with 95% confidence intervals (CI) was calculated. Seven studies including 667 ICH patients and 1821 ischemic stroke patients were identified for meta-analysis. Our results showed that Hcy levels in ICH patients were significantly higher than those in healthy controls (SMD?=?0.59, 95% CI?=?0.51-0.68, P??0.05); further subgroup analysis of ethnicity (Asians: SMD?=?0.57, 95% CI?=?0.48-0.66, P?

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC5803270 | biostudies-other | 2018 Feb

REPOSITORIES: biostudies-other

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Plasma homocysteine concentrations and risk of intracerebral hemorrhage: a systematic review and meta-analysis.

Zhou Zhike Z   Liang Yifan Y   Qu Huiling H   Zhao Mei M   Guo Feng F   Zhao Chuansheng C   Teng Weiyu W  

Scientific reports 20180207 1


Intracerebral hemorrhage (ICH) has the highest mortality rate in all strokes. However, controversy still exists concerning the association between plasma homocysteine (Hcy) and ICH. A systematic review and meta-analysis was conducted using Pubmed, Embase, and Web of Science up to April 18, 2017. Standard mean difference (SMD) for mean differences of plasma Hcy levels with 95% confidence intervals (CI) was calculated. Seven studies including 667 ICH patients and 1821 ischemic stroke patients were  ...[more]

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