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Acute acetaminophen ingestion improves performance and muscle activation during maximal intermittent knee extensor exercise.

ABSTRACT: Acetaminophen is a commonly used medicine for pain relief and emerging evidence suggests that it may improve endurance exercise performance. This study investigated some of the physiological mechanisms by which acute acetaminophen ingestion might blunt muscle fatigue development.Thirteen active males completed 60?×?3 s maximum voluntary contractions (MVC) of the knee extensors with each contraction separated by a 2 s passive recovery period. This protocol was completed 60 min after ingesting 1 g of maltodextrin (placebo) or 1 g of acetaminophen on two separate visits. Peripheral nerve stimulation was administered every 6th contraction for assessment of neuromuscular fatigue development, with the critical torque (CT), which reflects the maximal sustainable rate of oxidative metabolism, taken as the mean torque over the last 12 contractions. Surface electromyography was recorded continuously as a measure of muscle activation.Mean torque (61?±?11 vs. 58?±?14% pre-exercise MVC) and CT (44?±?13 vs. 40?±?15% pre-exercise MVC) were greater in the acetaminophen trial compared to placebo (both P??0.05). However, the decline in electromyography amplitude was attenuated in the acetaminophen trial, with electromyography amplitude being greater compared to placebo from 210 s onwards (P?

SUBMITTER: Morgan PT

PROVIDER: S-EPMC5805811 | biostudies-other | 2018 Mar

REPOSITORIES: biostudies-other

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Acute acetaminophen ingestion improves performance and muscle activation during maximal intermittent knee extensor exercise.

Morgan Paul T PT Bowtell Joanna L JL Vanhatalo Anni A Jones Andrew M AM Bailey Stephen J SJ

European journal of applied physiology 20180113 3

<h4>Aim</h4>Acetaminophen is a commonly used medicine for pain relief and emerging evidence suggests that it may improve endurance exercise performance. This study investigated some of the physiological mechanisms by which acute acetaminophen ingestion might blunt muscle fatigue development.<h4>Methods</h4>Thirteen active males completed 60 × 3 s maximum voluntary contractions (MVC) of the knee extensors with each contraction separated by a 2 s passive recovery period. This protocol was complete ...[more]

PMID: 29332237

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Project description:BackgroundIt has been shown that chronic ankle instability (CAI) leads to abnormalities in neuromuscular control of more proximal joints than the ankle. Although strength of the hip and the ankle muscles has been largely investigated providing concordant results, limited evidence with contrasting results has been reported regarding knee extensor and flexor muscles.PurposeTo investigate maximal and submaximal isometric muscle strength in individuals with CAI.Study designControlled laboratory study.MethodsFifteen participants with unilateral CAI and 15 healthy matched controls were recruited. To quantify maximal strength, peak forces were recorded during a maximal isometric voluntary contraction of knee extensor and flexor muscles at 30° and 90° of knee flexion and normalized by the body weight of each participant. At both angles, submaximal isometric contractions at 20%, 50%, and 80% of the maximal voluntary isometric contraction were performed to analyze strength steadiness, in terms of coefficient of variation, and strength accuracy, in terms of absolute error. During all the assessments, knee extensor and flexor muscle activation was recorded by means of surface electromyography.ResultsKnee flexor maximal isometric strength was significantly lower in the injured limb of individuals with CAI in comparison with healthy controls at both 30° (0.15 ± 0.05 vs 0.20 ± 0.05; P < .05) and 90° (0.14 ± 0.04 vs 0.18 ± 0.05; P < .05). Knee extensor and flexor steadiness was significantly lower (higher coefficient of variation) in both the injured and the noninjured limbs of individuals with CAI in comparison with healthy individuals at 90° and at 30° for knee flexor steadiness of the injured limb. Knee extensor and flexor accuracy was lower (higher absolute error) in both the injured and noninjured limbs of individuals with CAI in comparison with healthy individuals, mainly at 30°, while at 90° it was lower only in the injured limb. No differences between the 2 groups were found for maximal isometric strength of knee extensor muscles, as well as for muscle activations.ConclusionIndividuals with CAI show abnormalities in maximal and submaximal isometric strength of knee flexor muscles, and submaximal strength of the knee extensor muscles. Further studies should deeply investigate mechanisms leading to these abnormalities.Clinical relevanceRehabilitation interventions should consider abnormalities of neuromuscular control affecting joints more proximal than the ankle in individuals with CAI.RegistrationNCT05273177 (ClinicalTrials.gov identifier).

Dataset Information

Acute acetaminophen ingestion improves performance and muscle activation during maximal intermittent knee extensor exercise.

Publications

Acute acetaminophen ingestion improves performance and muscle activation during maximal intermittent knee extensor exercise.

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