Patterns of progressive atrophy vary with age in Alzheimer's disease patients.
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ABSTRACT:
SUBMITTER: Fiford CM
PROVIDER: S-EPMC5805840 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Publications
Patterns of progressive atrophy vary with age in Alzheimer's disease patients.
Fiford Cassidy M CM Ridgway Gerard R GR Cash David M DM Modat Marc M Nicholas Jennifer J Manning Emily N EN Malone Ian B IB Biessels Geert Jan GJ Ourselin Sebastien S Carmichael Owen T OT Cardoso M Jorge MJ Barnes Josephine J
Neurobiology of aging 20171114
Age is not only the greatest risk factor for Alzheimer's disease (AD) but also a key modifier of disease presentation and progression. Here, we investigate how longitudinal atrophy patterns vary with age in mild cognitive impairment (MCI) and AD. Data comprised serial longitudinal 1.5-T magnetic resonance imaging scans from 153 AD, 339 MCI, and 191 control subjects. Voxel-wise maps of longitudinal volume change were obtained and aligned across subjects. Local volume change was then modeled in te ...[more]
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