Ontology highlight
ABSTRACT:
SUBMITTER: Sammons MF
PROVIDER: S-EPMC5807870 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
ACS medicinal chemistry letters 20180119 2
Inhibitors of the renal outer medullary potassium channel (ROMK) show promise as novel mechanism diuretics, with potentially lower risk of diuretic-induced hypokalemia relative to current thiazide and loop diuretics. Here, we report the identification of a novel series of 3-sulfamoylbenzamide ROMK inhibitors. Starting from HTS hit <b>4</b>, this series was optimized to provide ROMK inhibitors with good in vitro potencies and well-balanced ADME profiles. In contrast to previously reported small-m ...[more]