Ontology highlight
ABSTRACT:
SUBMITTER: Mukkavilli R
PROVIDER: S-EPMC5813242 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Mukkavilli Rao R Yang Chunhua C Tanwar Reenu Singh RS Saxena Roopali R Gundala Sushma R SR Zhang Yingyi Y Ghareeb Ahmed A Floyd Stephan D SD Vangala Subrahmanyam S Kuo Wei-Wen WW Rida Padmashree C G PCG Aneja Ritu R
Scientific reports 20180214 1
Anticancer efficacy of ginger phenolics (GPs) has been demonstrated in various in vitro assays and xenograft mouse models. However, only sub-therapeutic plasma concentrations of GPs were detected in human and mouse pharmacokinetic (PK) studies. Intriguingly, a significant portion of GPs occurred as phase II metabolites (mainly glucuronide conjugates) in plasma. To evaluate the disposition of GPs and understand the real players responsible for efficacy, we performed a PK and tissue distribution s ...[more]