Ontology highlight
ABSTRACT:
SUBMITTER: Schmidtgall B
PROVIDER: S-EPMC5814856 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Chemistry (Weinheim an der Bergstrasse, Germany) 20171227 7
Non-natural oligonucleotides represent important (bio)chemical tools and potential therapeutic agents. Backbone modifications altering hybridization properties and biostability can provide useful analogues. Here, we employ an artificial nucleosyl amino acid (NAA) motif for the synthesis of oligonucleotides containing a backbone decorated with primary amines. An oligo-T sequence of this cationic DNA analogue shows significantly increased affinity for complementary DNA. Notably, hybridization with ...[more]