Ontology highlight
ABSTRACT:
SUBMITTER: Zheng M
PROVIDER: S-EPMC5816818 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Frontiers in cellular neuroscience 20180213
As a secreted axon guidance molecule, Netrin-1 has been documented to be a neuroprotective factor, which can reduce infarct volume, promote angiogenesis and anti-apoptosis after stroke in rodents. However, its role in axonal regeneration and synaptic formation after cerebral ischemic injury, and the related underlying mechanisms remain blurred. In this study, we used Adeno-associated vectors carrying Netrin-1 gene (AAV-NT-1) to up-regulate the expression level of Netrin-1 in rats' brain after mi ...[more]