Ontology highlight
ABSTRACT:
SUBMITTER: Gwee KA
PROVIDER: S-EPMC5817415 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Gwee Kok Ann KA Goh Vernadine V Lima Graca G Setia Sajita S
Journal of pain research 20180214
Nonsteroidal anti-inflammatory drugs (NSAIDs) are often coadministered with proton-pump inhibitors (PPIs) to reduce NSAID-induced gastrointestinal (GI) adverse events. This coadministration is generally regarded as safe, and is included in many of the guidelines on NSAID prescription. However, recent evidence indicates that the GI risks associated with NSAIDs can be potentiated when they are combined with PPIs. This review discusses the GI effects and complications of NSAIDs and how PPIs may pot ...[more]