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Association Between Use of Antithrombotic Medication and Hematuria-Related Complications.

ABSTRACT: Antithrombotic medications are among the most commonly prescribed medications.To characterize rates of hematuria-related complications among patients taking antithrombotic medications.Population-based, retrospective cohort study including all citizens in Ontario, Canada, aged 66 years and older between 2002 and 2014. The final follow-up date was December 31, 2014.Receipt of an oral anticoagulant or antiplatelet medication.Hematuria-related complications, defined as emergency department visit, hospitalization, or a urologic procedure to investigate or manage gross hematuria.Among 2?518?064 patients, 808?897 (mean [SD] age, 72.1 [6.8] years; 428?531 [53%] women) received at least 1 prescription for an antithrombotic agent over the study period. Over a median follow-up of 7.3 years, the rates of hematuria-related complications were 123.95 events per 1000 person-years among patients actively exposed to antithrombotic agents vs 80.17 events per 1000 person-years among patients not exposed to these drugs (difference, 43.8; 95% CI, 43.0-44.6; P?

SUBMITTER: Wallis CJD 

PROVIDER: S-EPMC5818855 | biostudies-other | 2017 Oct

REPOSITORIES: biostudies-other

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<h4>Importance</h4>Antithrombotic medications are among the most commonly prescribed medications.<h4>Objective</h4>To characterize rates of hematuria-related complications among patients taking antithrombotic medications.<h4>Design, setting, and participants</h4>Population-based, retrospective cohort study including all citizens in Ontario, Canada, aged 66 years and older between 2002 and 2014. The final follow-up date was December 31, 2014.<h4>Exposures</h4>Receipt of an oral anticoagulant or a  ...[more]