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Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options.


ABSTRACT: Recent studies have shown that breast cancer subtype can change from the primary tumour to the recurrence. Discordance between primary and recurrent breast cancer has implications for further treatment and ultimately prognosis. The aim of the study was to determine the rate of change between primary and recurrence of breast cancer and to assess the impact of these changes on survival and potential treatment options.Patient demographics were collected on those who underwent surgery for breast cancer between 2001 and 2014 and had a recurrence with biopsy results and pathology scoring of both the primary and recurrence.One hundred thirty two consecutive patients were included. There were 31 (23.5%) changes in subtype. Discordance occurred most frequently in luminal A breast cancer (n?=?20), followed by triple negative (n?=?4), luminal B (n?=?3) and HER2 (n?=?3). Patients who changed from luminal A to triple negative (n?=?18) had a significantly worse post-recurrence survival (p?

SUBMITTER: McAnena PF 

PROVIDER: S-EPMC5819681 | biostudies-other | 2018 Feb

REPOSITORIES: biostudies-other

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Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options.

McAnena Peter F PF   McGuire Andrew A   Ramli A A   Curran C C   Malone C C   McLaughlin R R   Barry K K   Brown James A L JAL   Kerin M J MJ  

BMC cancer 20180220 1


<h4>Background</h4>Recent studies have shown that breast cancer subtype can change from the primary tumour to the recurrence. Discordance between primary and recurrent breast cancer has implications for further treatment and ultimately prognosis. The aim of the study was to determine the rate of change between primary and recurrence of breast cancer and to assess the impact of these changes on survival and potential treatment options.<h4>Methods</h4>Patient demographics were collected on those w  ...[more]

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