Ontology highlight
ABSTRACT:
SUBMITTER: Ye R
PROVIDER: S-EPMC5824868 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Ye Risheng R Gordillo Ruth R Shao Mengle M Onodera Toshiharu T Chen Zhe Z Chen Shiuhwei S Lin Xiaoli X SoRelle Jeffrey A JA Li Xiaohong X Tang Miao M Keller Mark P MP Kuliawat Regina R Attie Alan D AD Gupta Rana K RK Holland William L WL Beutler Bruce B Herz Joachim J Scherer Philipp E PE
The Journal of clinical investigation 20180219 3
The compensatory proliferation of insulin-producing β cells is critical to maintaining glucose homeostasis at the early stage of type 2 diabetes. Failure of β cells to proliferate results in hyperglycemia and insulin dependence in patients. To understand the effect of the interplay between β cell compensation and lipid metabolism upon obesity and peripheral insulin resistance, we eliminated LDL receptor-related protein 1 (LRP1), a pleiotropic mediator of cholesterol, insulin, energy metabolism, ...[more]