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Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma.

ABSTRACT: Double-hit lymphomas (DHLs) and double-expressor lymphomas (DELs) are associated with resistance to frontline and salvage immunochemotherapy, as well as autologous stem cell transplantation (SCT). We hypothesized that allogeneic SCT (alloSCT) could overcome the chemoresistance associated with DEL/DHL. We retrospectively studied the impact of DEL/DHL status in a multicenter cohort of patients who underwent alloSCT for relapsed/refractory (rel/ref) aggressive B cell non-Hodgkin lymphoma (B-NHL). Seventy-eight patients transplanted at 3 centers in whom tumor tissue was available for immunohistochemistry and fluorescence in situ hybridization were enrolled; 47% had DEL and 13% had DHL. There were no significant differences in 4-year progression-free (PFS) or overall survival (OS) between patients with DEL compared with patients without DEL (PFS 30% versus 39%, P = .24; OS 31% versus 49%, P = .17) or between patients with DHL compared with patients without DHL (PFS 40% versus 34%, P = .62; OS 50% versus 38%, P = .46). The lack of association between DEL or DHL and outcome was confirmed in multivariable models, although inadequate sample size may have limited our ability to detect significant differences. In our cohort alloSCT produced durable remissions in patients with rel/ref aggressive B-NHL irrespective of DEL and DHL status, justifying its consideration in the treatment of patients with rel/ref DEL/DHL.

SUBMITTER: Herrera AF 

PROVIDER: S-EPMC5826860 | biostudies-other | 2018 Mar

REPOSITORIES: biostudies-other

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Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma.

Herrera Alex F AF   Rodig Scott J SJ   Song Joo Y JY   Kim Young Y   Griffin Gabriel K GK   Yang Dongyun D   Nikolaenko Liana L   Mei Matthew M   Bedell Victoria V   Dal Cin Paola P   Pak Christine C   Alyea Edwin P EP   Budde Lihua E LE   Chen Robert R   Chen Yi-Bin YB   Chan Wing C WC   Cutler Corey S CS   Ho Vincent T VT   Koreth John J   Krishnan Amrita A   Murata-Collins Joyce L JL   Nikiforow Sarah S   Palmer Joycelynne J   Pihan German A GA   Pillai Raju R   Popplewell Leslie L   Rosen Steven T ST   Siddiqi Tanya T   Sohani Aliyah R AR   Zain Jasmine J   Kwak Larry W LW   Weisenburger Dennis D DD   Weinstock David M DM   Soiffer Robert J RJ   Antin Joseph H JH   Forman Stephen J SJ   Nademanee Auayporn P AP   Armand Philippe P  

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20171128 3

Double-hit lymphomas (DHLs) and double-expressor lymphomas (DELs) are associated with resistance to frontline and salvage immunochemotherapy, as well as autologous stem cell transplantation (SCT). We hypothesized that allogeneic SCT (alloSCT) could overcome the chemoresistance associated with DEL/DHL. We retrospectively studied the impact of DEL/DHL status in a multicenter cohort of patients who underwent alloSCT for relapsed/refractory (rel/ref) aggressive B cell non-Hodgkin lymphoma (B-NHL). S  ...[more]