Ontology highlight
ABSTRACT:
SUBMITTER: Koch C
PROVIDER: S-EPMC5828201 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Koch Christine C Schwing Anna M AM Herrmann Eva E Borner Markus M Diaz-Rubio Eduardo E Dotan Efrat E Feliu Jaime J Okita Natsuko N Souglakos John J Arkenau Hendrik T HT Porschen Rainer R Koopman Miriam M Punt Cornelis J A CJA de Gramont Aimery A Tournigand Christophe C Zeuzem Stefan S Trojan Joerg J
Oncotarget 20171220 12
<h4>Background</h4>The aim of this meta-analysis was to evaluate efficacy and safety of first-line chemotherapy with or without a monoclonal antibody in elderly patients (≥ 70 years) with metastatic colorectal cancer (mCRC), since they are frequently underrepresented in clinical trials.<h4>Results</h4>Individual data from 10 studies were included. From a total of 3271 patients, 604 patients (18%) were ≥ 70 years (median 73 years, range 70-88). Of these, 335 patients were treated with a bevacizum ...[more]