Ontology highlight
ABSTRACT:
SUBMITTER: Solomon M
PROVIDER: S-EPMC5828774 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Solomon Melani M Muro Silvia S
Advanced drug delivery reviews 20170511
Lysosomes and lysosomal enzymes play a central role in numerous cellular processes, including cellular nutrition, recycling, signaling, defense, and cell death. Genetic deficiencies of lysosomal components, most commonly enzymes, are known as "lysosomal storage disorders" or "lysosomal diseases" (LDs) and lead to lysosomal dysfunction. LDs broadly affect peripheral organs and the central nervous system (CNS), debilitating patients and frequently causing fatality. Among other approaches, enzyme r ...[more]