Ontology highlight
ABSTRACT:
SUBMITTER: Abulaiti X
PROVIDER: S-EPMC5829306 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Abulaiti Xianmixinuer X Zhang Han H Wang Aifang A Li Na N Li Yang Y Wang Chenchen C Du Xiaojuan X Li Lingsong L
Stem cell reports 20171005 5
OCT4 is required to maintain the pluripotency of embryonic stem cells (ESCs); yet, overdose-expression of OCT4 induces ESC differentiation toward primitive endoderm. The molecular mechanism underlying this differentiation switch is not fully understood. Here, we found that substitution of threonine<sup>343</sup> by alanine (T343A), but not aspartic acid (T343D), caused a significant loss of OCT4-phosphorylation signal in ESCs. Loss of such OCT4-phosphorylation compromises its interaction with SO ...[more]