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Effect of an increased dosage of statins on spinal degenerative joint disease: a retrospective cohort study.

ABSTRACT: It has been proven that statin can protect synovial joints from developing osteoarthritis through its anti-inflammatory effects. However, studies on the effect of statins on spinal degenerative joint diseases are few and limited to in vitro studies. Therefore, we investigated the relationship between the statin dosage and the development of spinal degenerative joint diseases.A retrospective cohort study.Patients registered in Taiwan National Health Insurance Research Database.Patients aged 40-65 years old from 2001 to 2010 were included. Those who received statin treatment before 2001, were diagnosed with spinal degenerative joint diseases or received any spinal surgery before 2004 or had any spinal trauma before 2011 were excluded. A total of 7238 statin users and 164?454 non-users were identified and followed up for the next 7?years to trace the development of spinal degenerative joint disease.The incident rate of spinal degenerative joint diseases and HRs among the groups treated with different statin dosages.A higher dosage of statins was associated with a significantly lower risk of developing spinal degenerative joint disease in patients with hypercholesterolaemia. Compared with the group receiving less than 5400?mg of a statin, the HR of the 11?900-28 000?mg group was 0.83 (95% CI 0.70 to 0.99), and that of the group receiving more than 28?000?mg was 0.81 (95% CI 0.68 to 0.97). Results of subgroup analysis showed a significantly lower risk in men, those aged 50-59 years and those with a monthly income less than US$600.Our study's findings clearly indicated that a higher dosage of statins can reduce the incidence of spinal degenerative joint disease in patients with hypercholesterolaemia, and it can be beneficial for people with a higher risk of spine degeneration.

SUBMITTER: Cheng YY

PROVIDER: S-EPMC5829816 | biostudies-other | 2018 Feb

REPOSITORIES: biostudies-other

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Effect of an increased dosage of statins on spinal degenerative joint disease: a retrospective cohort study.

Cheng Yuan-Yang YY Kao Chung-Lan CL Lin Shih-Yi SY Chang Shin-Tsu ST Wei Tz-Shiang TS Chang Shih-Ni SN Lin Ching-Heng CH

BMJ open 20180208 2

<h4>Objectives</h4>It has been proven that statin can protect synovial joints from developing osteoarthritis through its anti-inflammatory effects. However, studies on the effect of statins on spinal degenerative joint diseases are few and limited to in vitro studies. Therefore, we investigated the relationship between the statin dosage and the development of spinal degenerative joint diseases.<h4>Design</h4>A retrospective cohort study.<h4>Setting</h4>Patients registered in Taiwan National Heal ...[more]

PMID: 29439066

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Project description:The facet joint is a crucial anatomic region of the spine owing to its biomechanical role in facilitating articulation of the vertebrae of the spinal column. It is a diarthrodial joint with opposing articular cartilage surfaces that provide a low friction environment and a ligamentous capsule that encloses the joint space. Together with the disc, the bilateral facet joints transfer loads and guide and constrain motions in the spine due to their geometry and mechanical function. Although a great deal of research has focused on defining the biomechanics of the spine and the form and function of the disc, the facet joint has only recently become the focus of experimental, computational and clinical studies. This mechanical behavior ensures the normal health and function of the spine during physiologic loading but can also lead to its dysfunction when the tissues of the facet joint are altered either by injury, degeneration or as a result of surgical modification of the spine. The anatomical, biomechanical and physiological characteristics of the facet joints in the cervical and lumbar spines have become the focus of increased attention recently with the advent of surgical procedures of the spine, such as disc repair and replacement, which may impact facet responses. Accordingly, this review summarizes the relevant anatomy and biomechanics of the facet joint and the individual tissues that comprise it. In order to better understand the physiological implications of tissue loading in all conditions, a review of mechanotransduction pathways in the cartilage, ligament and bone is also presented ranging from the tissue-level scale to cellular modifications. With this context, experimental studies are summarized as they relate to the most common modifications that alter the biomechanics and health of the spine-injury and degeneration. In addition, many computational and finite element models have been developed that enable more-detailed and specific investigations of the facet joint and its tissues than are provided by experimental approaches and also that expand their utility for the field of biomechanics. These are also reviewed to provide a more complete summary of the current knowledge of facet joint mechanics. Overall, the goal of this review is to present a comprehensive review of the breadth and depth of knowledge regarding the mechanical and adaptive responses of the facet joint and its tissues across a variety of relevant size scales.

Dataset Information

Effect of an increased dosage of statins on spinal degenerative joint disease: a retrospective cohort study.

Publications

Effect of an increased dosage of statins on spinal degenerative joint disease: a retrospective cohort study.

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