Dataset Information

Longitudinal changes in intraocular pressure and association with systemic factors and refractive error: Lingtou Eye Cohort Study.

ABSTRACT: OBJECTIVES:To investigate the longitudinal changes in intraocular pressure (IOP) and its associations with refractive error and systemic determinants in a Chinese geriatric population. DESIGN:Prospective cohort study. SETTING:Guangzhou Government Servant Physical Check-up Center, Guangzhou, China. PARTICIPANTS:4413 government employees aged no less than 40 years (41.9% female) attending annual physical and eye examinations were included in this study. The inclusion criterion was having attended the 2010 follow-up examination. The exclusion criteria include glaucoma or intraocular surgery history, IOP >21?mm Hg at any visit or without available IOP data at all visits from 2010 to 2014. PRIMARY AND SECONDARY OUTCOME MEASURES:The outcome measure was IOP at each follow-up visit from 2010 to 2014. Mixed-effect model was used to assess the relationship between longitudinal changes in IOP and potential risk factors. RESULTS:For the 2653 participants who had available IOP data at both the 2010 and 2014 follow-up visits, the average change in IOP was an increase of 0.43 (95% CI 0.36 to 0.50)?mm Hg. For the whole study population and in the optimised mixed model, there was a non-linear increase of IOP with age (P<0.001), with greater changes in younger subjects and in women (P<0.001?and P=0.002, respectively). Elevations in systolic blood pressure, diastolic blood pressure, body mass index (BMI) and fasting plasma glucose (FPG), as well as a myopic shift (all with P<0.001), during the follow-up were associated with an increasing trend of IOP, while serum lipids were found to be not significantly associated. CONCLUSIONS:In this cohort of elderly Chinese adults, IOP increases non-linearly with ageing. People with increasing blood pressure, BMI, FPG and myopic progression are more likely to have IOP elevation over time.

SUBMITTER: Han X

PROVIDER: S-EPMC5829881 | biostudies-other | 2018 Feb

REPOSITORIES: biostudies-other

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Longitudinal changes in intraocular pressure and association with systemic factors and refractive error: Lingtou Eye Cohort Study.

Han Xiaotong X Yang Tangjian T Zhang Jian J Yu Sha S Guo Xinxing X Yan William W Hu Yin Y He Mingguang M

BMJ open 20180214 2

<h4>Objectives</h4>To investigate the longitudinal changes in intraocular pressure (IOP) and its associations with refractive error and systemic determinants in a Chinese geriatric population.<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>Guangzhou Government Servant Physical Check-up Center, Guangzhou, China.<h4>Participants</h4>4413 government employees aged no less than 40 years (41.9% female) attending annual physical and eye examinations were included in this study. The inclusion c ...[more]

PMID: 29444785

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Dataset Information

Longitudinal changes in intraocular pressure and association with systemic factors and refractive error: Lingtou Eye Cohort Study.

Publications

Longitudinal changes in intraocular pressure and association with systemic factors and refractive error: Lingtou Eye Cohort Study.

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