Ontology highlight
ABSTRACT:
SUBMITTER: Hansen IS
PROVIDER: S-EPMC5830413 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Hansen Ivo S IS Krabbendam Lisette L Bernink Jochem H JH Loayza-Puch Fabricio F Hoepel Willianne W van Burgsteden Johan A JA Kuijper Elsa C EC Buskens Christianne J CJ Bemelman Willem A WA Zaat Sebastiaan A J SAJ Agami Reuven R Vidarsson Gestur G van den Brink Gijs R GR de Jong Esther C EC Wildenberg Manon E ME Baeten Dominique L P DLP Everts Bart B den Dunnen Jeroen J
Nature communications 20180228 1
CD103<sup>+</sup> dendritic cells (DC) are crucial for regulation of intestinal tolerance in humans. However, upon infection of the lamina propria this tolerogenic response is converted to an inflammatory response. Here we show that immunoglobulin A (IgA) immune complexes (IgA-IC), which are present after bacterial infection of the lamina propria, are important for the induction of inflammation by the human CD103<sup>+</sup>SIRPα<sup>+</sup> DC subset. IgA-IC, by recognition through FcαRI, selec ...[more]