Ontology highlight
ABSTRACT:
SUBMITTER: Bazaid AS
PROVIDER: S-EPMC5832852 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Bazaid Abdulrahman S AS Forbes Sarah S Humphreys Gavin J GJ Ledder Ruth G RG O'Cualain Ronan R McBain Andrew J AJ
Scientific reports 20180301 1
Staphylococcus aureus can develop a small colony variant (SCV) phenotype in response to sub-lethal exposure to the biocide triclosan. In the current study, whole genome sequencing was performed and changes in virulence were investigated in five Staphylococcus aureus strains following repeated exposure to triclosan. Following exposure, 4/5 formed SCV and exhibited point mutations in the triclosan target gene fabI with 2/4 SCVs showing mutations in both fabI and fabD. The SCV phenotype was in all ...[more]