Revisiting the definition of estrogen receptor positivity in HER2-negative primary breast cancer.
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ABSTRACT:
SUBMITTER: Fujii T
PROVIDER: S-EPMC5834134 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Publications
Revisiting the definition of estrogen receptor positivity in HER2-negative primary breast cancer.
Fujii T T Kogawa T T Dong W W Sahin A A AA Moulder S S Litton J K JK Tripathy D D Iwamoto T T Hunt K K KK Pusztai L L Lim B B Shen Y Y Ueno N T NT
Annals of oncology : official journal of the European Society for Medical Oncology 20171001 10
<h4>Background</h4>Although 1% has been used as cut-off for estrogen receptor (ER) positivity, several studies have reported that tumors with ER < 1% have characteristics similar to those with 1% ≤ ER < 10%. We hypothesized that in patients with human epidermal growth factor 2 (HER2)-negative breast cancer, a cut-off of 10% is more useful than one of 1% in discriminating for both a better pathological complete response (pCR) rate to neoadjuvant chemotherapy and a better long-term outcome with ad ...[more]
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