Ontology highlight
ABSTRACT:
SUBMITTER: Longuespee R
PROVIDER: S-EPMC5834865 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Longuespée Rémi R Wefers Annika K AK De Vita Elena E Miller Aubry K AK Reuss David E DE Wick Wolfgang W Herold-Mende Christel C Kriegsmann Mark M Schirmacher Peter P von Deimling Andreas A Pusch Stefan S
Acta neuropathologica communications 20180302 1
All isocitrate dehydrogenase (IDH) mutant solid neoplasms exhibit highly elevated levels of D-2-hydroxyglutarate (D-2HG). Detection of 2HG in tumor tissues currently is performed by gas or liquid chromatography-mass spectrometry (GC- or LC-MS) or biochemical detection. While these methods are highly accurate, a considerable amount of time for tissue preparation and a relatively high amount of tissue is required for testing. We here present a rapid approach to detect 2HG in brain tumor tissue bas ...[more]