Identification of novel enriched recurrent chimeric COL7A1-UCN2 in human laryngeal cancer samples using deep sequencing.
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ABSTRACT:
SUBMITTER: Tao Y
PROVIDER: S-EPMC5834868 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Publications
Identification of novel enriched recurrent chimeric COL7A1-UCN2 in human laryngeal cancer samples using deep sequencing.
Tao Ye Y Gross Neil N Fan Xiaojiao X Yang Jianming J Teng Maikun M Li Xu X Li Guojun G Zhang Yang Y Huang Zhigang Z
BMC cancer 20180302 1
<h4>Background</h4>As hybrid RNAs, transcription-induced chimeras (TICs) may have tumor-promoting properties, and some specific chimeras have become important diagnostic markers and therapeutic targets for cancer.<h4>Methods</h4>We examined 23 paired laryngeal cancer (LC) tissues and adjacent normal mucous membrane tissue samples (ANMMTs). Three of these pairs were used for comparative transcriptomic analysis using high-throughput sequencing. Furthermore, we used real-time polymerase chain react ...[more]
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