Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Q
PROVIDER: S-EPMC5835695 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Zhang Qiyue Q Wang Jingyuan J Li Na N Liu Zhentao Z Chen Zuhua Z Li Zhongwu Z Lai Yumei Y Shen Lin L Gao Jing J
American journal of cancer research 20180201 2
This study was designed to investigate the significance of the effect of miR-34a on 5-fluorouracil (5-FU) sensitivity <i>in vitro</i> and <i>in vivo</i>. miR-34a expression in tumor tissues or serum was determined by quantitative polymerase chain reaction. CRC cell lines HCT116 and SW480 were used to evaluate cell viability, cell apoptosis, and the cell cycle using a cell proliferation assay, flow cytometry, and Western blotting, respectively. For the <i>in vivo</i> studies, xenografts derived f ...[more]