Achieving Biocompatible SABRE: An in?vitro Cytotoxicity Study.
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ABSTRACT:
SUBMITTER: Manoharan A
PROVIDER: S-EPMC5838797 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
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Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study.
Manoharan Anand A Rayner Peter J PJ Iali Wissam W Burns Michael J MJ Perry V Hugh VH Perry V Hugh VH Duckett Simon B SB
ChemMedChem 20180118 4
Production of a biocompatible hyperpolarized bolus for signal amplification by reversible exchange (SABRE) could open the door to simple clinical diagnosis via magnetic resonance imaging. Essential to successful progression to preclinical/clinical applications is the determination of the toxicology profile of the SABRE reaction mixture. Herein, we exemplify the cytotoxicity of the SABRE approach using in vitro cell assays. We conclude that the main cause of the observed toxicity is due to the SA ...[more]
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