Ontology highlight
ABSTRACT:
SUBMITTER: Hecht AL
PROVIDER: S-EPMC5839110 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Hecht Aaron L AL Casterline Benjamin W BW Choi Vivian M VM Bubeck Wardenburg Juliane J
Cell host & microbe 20170921 4
Intestinal microbes are recognized for their role in human disease. Enterotoxigenic Bacteroides fragilis (ETBF) has been implicated in inflammatory bowel disease and colorectal cancer; however, colonization alone is insufficient to cause these illnesses. We hypothesized that homeostasis in healthy carriers is maintained by colonic mucus, the major constituent of which is the glycoprotein Muc2. We found that Muc2-deficient mice succumb to lethal disease from ETBF colonization in a B. fragilis tox ...[more]