Ontology highlight
ABSTRACT:
SUBMITTER: Miyazaki H
PROVIDER: S-EPMC5839369 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Miyazaki Hiroaki H Takahashi Ryou-U RU Prieto-Vila Marta M Kawamura Yumi Y Kondo Seiji S Shirota Tatsuo T Ochiya Takahiro T
Oncotarget 20180113 11
A number of studies report that epithelial to mesenchymal transition (EMT) supports the generation and maintenance of cancer stem cells (CSCs), which show tumor seeding ability and drug resistance; however, the molecular mechanisms underlying induction of EMT-associated tumor malignancy remain unclear. The present study reports that oral cancer cells switch from expressing the CD44 variant form (CD44v) to expressing the standard form (CD44s) during acquisition of cisplatin-resistance, which resu ...[more]