Ontology highlight
ABSTRACT:
SUBMITTER: Tsoumpekos G
PROVIDER: S-EPMC5839783 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Tsoumpekos Giorgos G Nemetschke Linda L Knust Elisabeth E
The Journal of cell biology 20180111 3
Growth of epithelial tissues is regulated by a plethora of components, including signaling and scaffolding proteins, but also by junctional tension, mediated by the actomyosin cytoskeleton. However, how these players are spatially organized and functionally coordinated is not well understood. Here, we identify the <i>Drosophila melanogaster</i> scaffolding protein Big bang as a novel regulator of growth in epithelial cells of the wing disc by ensuring proper junctional tension. Loss of <i>big ba ...[more]