Ontology highlight
ABSTRACT:
SUBMITTER: Petsalaki E
PROVIDER: S-EPMC5839794 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Petsalaki Eleni E Dandoulaki Maria M Zachos George G
The Journal of cell biology 20180123 3
The mitotic spindle checkpoint delays anaphase onset in the presence of unattached kinetochores, and efficient checkpoint signaling requires kinetochore localization of the Rod-ZW10-Zwilch (RZZ) complex. In the present study, we show that human Chmp4c, a protein involved in membrane remodeling, localizes to kinetochores in prometaphase but is reduced in chromosomes aligned at the metaphase plate. Chmp4c promotes stable kinetochore-microtubule attachments and is required for proper mitotic progre ...[more]