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Vascular robustness: The missing parameter in cardiovascular risk prediction.


ABSTRACT: Undetected high risk for premature death of cardiovascular disease (CVD) among individuals with low-to-moderate risk factor scores is an acknowledged obstacle to CVD prevention. The vasculature's functional robustness against risk factor derailment may serve as a novel discriminator of mortality risk under similar risk factor loads. To test this assumption, we hypothesized that the expected inverse robustness-mortality association is verifiable as a significant trend along the age spectrum of risk factor-challenged cohorts. This is a retrospective cohort study of 372 adults (mean age 56.1?years, range 21-92; 45% female) with a variety of CV risk factors. An arterial model (VascAssist 2, iSYMED GmbH, Germany) was used to derive global parameters of arterial function from non-invasively acquired pulse pressure waves. Participants were stratified by health status: apparently healthy (AH; n?=?221); with hypertension and/or hypercholesterolemia (CC; n?=?61); with history of CV event(s) (CVE; n?=?90). Multivariate linear regression was used to derive a robustness score which was calibrated against the CVD mortality hazard rate of a sub-cohort of the LURIC study (n?=?1369; mean age 59.1?years, range 20-75; 37% female). Robustness correlated linearly with calendar age in CC (F(1, 59)?=?10.42; p?

SUBMITTER: Kraushaar LE 

PROVIDER: S-EPMC5840857 | biostudies-other | 2018 Mar

REPOSITORIES: biostudies-other

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Vascular robustness: The missing parameter in cardiovascular risk prediction.

Kraushaar Lutz E LE   Dressel Alexander A   Maßmann Alexander A  

Preventive medicine reports 20180128


Undetected high risk for premature death of cardiovascular disease (CVD) among individuals with low-to-moderate risk factor scores is an acknowledged obstacle to CVD prevention. The vasculature's functional robustness against risk factor derailment may serve as a novel discriminator of mortality risk under similar risk factor loads. To test this assumption, we hypothesized that the expected inverse robustness-mortality association is verifiable as a significant trend along the age spectrum of ri  ...[more]

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