Delivery of monocyte lineage cells in a biomimetic scaffold enhances tissue repair.
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ABSTRACT:
SUBMITTER: Hu MS
PROVIDER: S-EPMC5841872 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Publications
Delivery of monocyte lineage cells in a biomimetic scaffold enhances tissue repair.
Hu Michael S MS Walmsley Graham G GG Barnes Leandra A LA Weiskopf Kipp K Rennert Robert C RC Duscher Dominik D Januszyk Michael M Maan Zeshaan N ZN Hong Wan Xing WX Cheung Alexander Tm AT Leavitt Tripp T Marshall Clement D CD Ransom Ryan C RC Malhotra Samir S Moore Alessandra L AL Rajadas Jayakumar J Lorenz H Peter HP Weissman Irving L IL Gurtner Geoffrey C GC Longaker Michael T MT
JCI insight 20171005 19
The monocyte lineage is essential to normal wound healing. Macrophage inhibition or knockout in mice results in impaired wound healing through reduced neovascularization, granulation tissue formation, and reepithelialization. Numerous studies have either depleted macrophages or reduced their activity in the context of wound healing. Here, we demonstrate that by increasing the number of macrophages or monocytes in the wound site above physiologic levels via pullulan-collagen composite dermal hydr ...[more]
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