Ontology highlight
ABSTRACT:
SUBMITTER: Ying C
PROVIDER: S-EPMC5843840 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Ying Chang C Xiao Bo-Duan BD Qin Yun Y Wang Bin-Rong BR Liu Xin-Yuan XY Wang Ru-Wei RW Fang Ling L Yan Hui H Zhou Xiu-Mei XM Wang Yi-Gang YG
Acta pharmacologica Sinica 20170907 3
GOLPH2 (also called GP73) is a Golgi glycoprotein, which has been identified as a novel tumor marker upregulated in various cancers, including prostate cancer (PCa). GD55 is a novel GOLPH2-regulated oncolytic adenovirus that exhibits a strong killing effect on hepatoma cells. Here, we investigate the antitumor effect of GD55 on prostate cancer stem cell (CSC)-like cells in vitro and in vivo. Prostate CSC-like sphere cells were acquired and enriched by culturing DU145, LNCap or P3 prostate cancer ...[more]