Ontology highlight
ABSTRACT:
SUBMITTER: Zhao SJ
PROVIDER: S-EPMC5844886 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Cell death & disease 20180309 3
Cellular metabolic reprogramming is the main characteristic of cancer cells and identification of targets using this metabolic pattern is extremely important to treat cancers, such as osteosarcoma (OS). In this study, SLIT2 and ROBO1 were upregulated in OS, and higher expression of ROBO1 was associated with worse overall survival rate. Furthermore, in vitro and in vivo experiments demonstrated that the SLIT2/ROBO1 axis promotes proliferation, inhibits apoptosis, and contributes to the Warburg ef ...[more]