Ontology highlight
ABSTRACT:
SUBMITTER: Hwang JJ
PROVIDER: S-EPMC5846903 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Hwang Janice J JJ Jiang Lihong L Hamza Muhammad M Sanchez Rangel Elizabeth E Dai Feng F Belfort-DeAguiar Renata R Parikh Lisa L Koo Brian B BB Rothman Douglas L DL Mason Graeme G Sherwin Robert S RS
JCI insight 20171019 20
In rodent models, obesity and hyperglycemia alter cerebral glucose metabolism and glucose transport into the brain, resulting in disordered cerebral function as well as inappropriate responses to homeostatic and hedonic inputs. Whether similar findings are seen in the human brain remains unclear. In this study, 25 participants (9 healthy participants; 10 obese nondiabetic participants; and 6 poorly controlled, insulin- and metformin-treated type 2 diabetes mellitus (T2DM) participants) underwent ...[more]