Ontology highlight
ABSTRACT:
SUBMITTER: Pietrocola F
PROVIDER: S-EPMC5848858 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Cell reports 20180201 9
The age-associated deterioration in cellular and organismal functions associates with dysregulation of nutrient-sensing pathways and disabled autophagy. The reactivation of autophagic flux may prevent or ameliorate age-related metabolic dysfunctions. Non-toxic compounds endowed with the capacity to reduce the overall levels of protein acetylation and to induce autophagy have been categorized as caloric restriction mimetics (CRMs). Here, we show that aspirin or its active metabolite salicylate in ...[more]