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Deciphering Possible Association of Risk Factors for Dental Caries in Pakistani Population.

ABSTRACT: Obesity is a state of abnormal accumulation of fat in adipose tissues of the body to the level that one's health is adversely compromised. Tripathi et al. state (according to WHO) that obesity is now considered the fifth leading cause of mortality in the world. Caries is a multifactorial disease and one of the major oral health issues of the modern era affecting people around the globe. Rise in dental caries has been observed in developing countries as a result of factors including increased intake of carbohydrates. The present study aims for assessing the association of DMFT with BMI, age, and gender. This study was conducted in the dental OPD of the Dow University of Health Sciences, Karachi, from February 2016 till January 2017. A custom-made interview-based questionnaire was used to assess BMI, DMFT, and sociodemographics. The sample size was kept at 385. Age was reported as a strong predictor (R2 0.641) of DMFT followed by BMI and gender as the weakest predictors. Age and BMI had statistically significant association with DMFT scores, which shows that diet patterns may affect general health. High caloric intake over long periods affects BMI and also oral health.

SUBMITTER: Maqsood S

PROVIDER: S-EPMC5851031 | biostudies-other | 2018

REPOSITORIES: biostudies-other

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Deciphering Possible Association of Risk Factors for Dental Caries in Pakistani Population.

Maqsood Shahida S Baber Hasan H Abbas Zia Z Ali Khan Javeria J Khalid Muznah M

International journal of dentistry 20180228

Obesity is a state of abnormal accumulation of fat in adipose tissues of the body to the level that one's health is adversely compromised. Tripathi et al. state (according to WHO) that obesity is now considered the fifth leading cause of mortality in the world. Caries is a multifactorial disease and one of the major oral health issues of the modern era affecting people around the globe. Rise in dental caries has been observed in developing countries as a result of factors including increased int ...[more]

PMID: 29681939

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Project description:Aim:Dental enamel, the most rigid biological tissue of the tooth known to mankind, is the most integral and fundamental part of the tooth. Enamel matrixes compile 5% of Enamelin peptides and at the time of tooth development, they are considered to effect the formation and elongation of enamel crystallites. ENAM plays critical role in enamel formation. Any changes in ENAM may affect the thickness of enamel and may lead to dental caries. The present study is aimed to evaluate the association of ENAM gene polymorphisms and susceptibility of dental caries development risk. Material and methods:The present study was carried out on 168 South Indian children, children's with dental caries were included in study. Written consent was taken from their parents/guardians. Additionally 193 healthy individuals were enrolled as controls. Sampling was done after dental examination of the individuals. Three ENAM gene single nucleotide polymorphisms (SNPs) were rs7671281, rs3796704 and rs12640848 was genotyped to check their role in susceptibility of dental caries development risk. Results:Out of three SNPs rs7671281 showed statistically significant risk association with dental caries susceptibility in this ethnic population at heterozygous allele CT (OR: 1.939, p?=?.01865) and with minor allele T (OR: 1.451, p?=?.001292). SNP rs3796704 showed significant protective association with dental caries in Indian population at heterozygous allele GA (OR: 0.409, p?=?.0192) and with minor allele A (OR: 0.645, p?=?.00875). SNP rs12640848 showed significant protective association with dental caries in Indian population at heterozygous allele AG (OR: 3.041, p?=?.00642) and with minor allele G (OR: 1.478, p?=?.02184). Preliminary insilico analysis also showed that rs7671281 (Ile648Thr) amino acid change will cause the structural and functional changes in ENAM protein. Conclusions:In the present study significant association was observed between ENAM gene SNP rs7671281 and dental caries susceptibility in South Indian children. These results suggested that ENAM gene variants may contribute to dental caries in children.

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Deciphering Possible Association of Risk Factors for Dental Caries in Pakistani Population.

Publications

Deciphering Possible Association of Risk Factors for Dental Caries in Pakistani Population.

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