Ontology highlight
ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC5855694 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Sun Yanqin Y Zeng Chao C Gan Siyuan S Li Hongmei H Cheng Ying Y Chen Dongjie D Li Rujia R Zhu Wei W
International journal of molecular sciences 20180206 2
As the most common cause of cancer death in women, the pathogenesis of breast cancer still remains unclear. Here, we reported a long non-coding RNA (lncRNA), HOTTIP (HOXA transcript at the distal tip), that may play an important role in the pathogenesis of breast cancer. Using gain-and-loss-of experiments in vitro and in vivo, we observed the marked upregulation of HOTTIP/HOXA11 in the breast cancer cell line, MCF-7, and the downregulation of HOTTIP or HOXA11, which might inhibit cell proliferat ...[more]