Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC5856711 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
Chen Xiaoyan X Xue Bao B Wang Jun J Liu Haixia H Shi Limin L Xie Junxia J
Neuroscience bulletin 20170907 2
The pathogenesis of the second major neurodegenerative disorder, Parkinson's disease (PD), is closely associated with the dysfunction of potassium (K<sup>+</sup>) channels. Therefore, PD is also considered to be an ion channel disease or neuronal channelopathy. Mounting evidence has shown that K<sup>+</sup> channels play crucial roles in the regulations of neurotransmitter release, neuronal excitability, and cell volume. Inhibition of K<sup>+</sup> channels enhances the spontaneous firing freque ...[more]