Ontology highlight
ABSTRACT:
SUBMITTER: Wu YP
PROVIDER: S-EPMC5872805 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Wu Yung-Peng YP Chew Chee Ying CY Li Tian-Neng TN Chung Tzu-Hsuan TH Chang En-Hao EH Lam Chak Hin CH Tan Kui-Thong KT
Chemical science 20171117 3
Target-activated chemical probes are important tools in basic biological research and medical diagnosis for monitoring enzyme activities and reactive small molecules. Based on the fluorescence turn-on mechanism, they can be divided into two classes: dye-based fluorescent probes and caged-luciferin. In this paper, we introduce a new type of chemical probe in which the fluorescence turn-on is based on controlled streptavidin-biotin binding. Compared to conventional probes, the streptavidin-biotin ...[more]