Prevalence of drug-drug interactions in geriatric patients at an ambulatory care pharmacy in a tertiary care teaching hospital.

ABSTRACT: A cross-sectional study was performed from February to May 2015, to estimate the prevalence of drug-drug interactions in geriatric patients at the ambulatory care pharmacy at King Abdul-Aziz Medical City in Jeddah, Saudi Arabia.A total of 310 patients were included, with a mean age (±?SD) of 73.78?±?6.96, and 48.70% were female. The overall prevalence of DDIs of all categories was 90.64%. Category B DDIs was 55.80%, category C DDIs 87.74%, category D DDIs 51.93%, and category X DDIs 16.45%. Atorvastatine plus omeprazole was identified as the most common interacting pair, with a prevalence of 25.26%. Multivariate logistic regression analysis showed that category D or X DDIs are more likely to occur in the female patient (OR?=?1.79; 95% CI 1.07, 2.97), the patient taking more than three medications (OR?=?22.62; 95% CI 2.93, 174.83), and the patient with more than two conditions (OR?=?3.09; 95% CI 1.81, 5.27).

SUBMITTER: Aljadani R 

PROVIDER: S-EPMC5887202 | biostudies-other | 2018 Apr

REPOSITORIES: biostudies-other