Ontology highlight
ABSTRACT:
SUBMITTER: George A
PROVIDER: S-EPMC5891370 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Bioorganic & medicinal chemistry 20180216 8
Androgen receptor (AR) signaling is vital to the viability of all forms of prostate cancer (PCa). With the goal of investigating the effect of simultaneous inhibition and depletion of AR on viability of PCa cells, we designed, synthesized and characterized the bioactivities of bifunctional agents which incorporate the independent cancer killing properties of an antiandrogen and genistein, and the AR downregulation effect of genistein within a single molecular template. We observed that a represe ...[more]