Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa.
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ABSTRACT:
SUBMITTER: Dandela R
PROVIDER: S-EPMC5897874 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Publications
Proteome-wide mapping of PQS-interacting proteins in <i>Pseudomonas aeruginosa</i>.
Dandela Rambabu R Mantin Danielle D Cravatt Benjamin F BF Rayo Josep J Meijler Michael M MM
Chemical science 20180119 8
The opportunistic human pathogen <i>Pseudomonas aeruginosa</i> secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins. The revealed quinolone interactome contains both known as well as newly identified virulence factors and presents new targets for the treatment of bacterial infections. ...[more]
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