Ontology highlight
ABSTRACT:
SUBMITTER: Tan PS
PROVIDER: S-EPMC5898484 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Tan Piau Siong PS Aramburu Iker Valle IV Mercadante Davide D Tyagi Swati S Chowdhury Aritra A Spitz Daniel D Shammas Sarah L SL Gräter Frauke F Lemke Edward A EA
Cell reports 20180301 13
Phenylalanine-glycine-rich nucleoporins (FG-Nups) are intrinsically disordered proteins, constituting the selective barrier of the nuclear pore complex (NPC). Previous studies showed that nuclear transport receptors (NTRs) were found to interact with FG-Nups by forming an "archetypal-fuzzy" complex through the rapid formation and breakage of interactions with many individual FG motifs. Here, we use single-molecule studies combined with atomistic simulations to show that, in sharp contrast, FG-Nu ...[more]