Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC5898890 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Li Sanming S Ning Ke K Zhou Jing J Guo Yuli Y Zhang Houjian H Zhu Yu Y Zhang Liying L Jia Changkai C Chen Yongxiong Y Sol Reinach Peter P Liu Zuguo Z Li Wei W
Experimental & molecular medicine 20180302 3
Sleep deficiency is a common public health problem associated with many diseases, such as obesity and cardiovascular disease. In this study, we established a sleep deprivation (SD) mouse model using a 'stick over water' method and observed the effect of sleep deficiency on ocular surface health. We found that SD decreased aqueous tear secretion; increased corneal epithelial cell defects, corneal sensitivity, and apoptosis; and induced squamous metaplasia of the corneal epithelium. These patholog ...[more]