Ontology highlight
ABSTRACT:
SUBMITTER: Kim JK
PROVIDER: S-EPMC5903819 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Kim Jeong-Ki JK Kim Injung I Choi Keonwoo K Choi Jee-Hyun JH Kim Eunmin E Lee Hwa-Young HY Park Jongkeun J Kim Yoon Sungjoo S
Experimental & molecular medicine 20180209 2
During the hair follicle (HF) cycle, HR protein expression is not concordant with the presence of the Hr mRNA transcript, suggesting an elaborate regulation of Hr gene expression. Here we present evidence that the 5' untranslated region (UTR) of the Hr gene has internal ribosome entry site (IRES) activity and this activity is regulated by the binding of poly (rC) binding protein 2 (PCBP2) to Hr mRNA. Overexpression and knockdown of PCBP2 resulted in a decrease in Hr 5' UTR IRES activity and an i ...[more]