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Systematic review of the relationship of Helicobacter pylori infection with geographical latitude, average annual temperature and average daily sunshine.

ABSTRACT: Helicobacter pylori (H. pylori) infection is a worldwide threat to human health with high prevalence. In this study, we analyzed the relationship between latitude, average annual temperature, average daily sunshine time and H. pylori infection.The PubMed, ClinicalTrials.gov , EBSCO and Web of Science databases were searched to identify studies reporting H. pylori infection. Latitude 30° was the cut-off level for low and mid-latitude areas. We obtained information for latitude, average annual temperature, average daily sunshine, and Human Development Index (HDI) from reports of studies of the relationships with H. pylori infection.Of the 51 studies included, there was significant difference in H. pylori infection between the low- and mid-latitude areas (P?=?0.05). There was no significant difference in the prevalence of H. pylori infection in each 15°-latitude zone analyzed (P?=?0.061). Subgroup analysis revealed the highest and lowest H. pylori infection rates in the developing regions at >?30° latitude subgroup and the developed regions at

SUBMITTER: Lu C

PROVIDER: S-EPMC5905136 | biostudies-other | 2018 Apr

REPOSITORIES: biostudies-other

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Systematic review of the relationship of Helicobacter pylori infection with geographical latitude, average annual temperature and average daily sunshine.

Lu Chao C Yu Ye Y Li Lan L Yu Chaohui C Xu Ping P

BMC gastroenterology 20180417 1

<h4>Background</h4>Helicobacter pylori (H. pylori) infection is a worldwide threat to human health with high prevalence. In this study, we analyzed the relationship between latitude, average annual temperature, average daily sunshine time and H. pylori infection.<h4>Methods</h4>The PubMed, ClinicalTrials.gov , EBSCO and Web of Science databases were searched to identify studies reporting H. pylori infection. Latitude 30° was the cut-off level for low and mid-latitude areas. We obtained informati ...[more]

PMID: 29665777

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Project description:Background: Penicillins inhibit cell wall synthesis; therefore, H. pylori must be dividing for these antibiotics to be effective. Identifying growth responses to varying medium pH may allow design of more effective treatment regimens. Aim: To determine the effect of acidity on bacterial growth and the bactericidal efficacy of ampicillin. Methods: H. pylori were incubated in dialysis chambers suspended in 1.5L of media at various pHs with 5mM urea, with or without ampicillin, for 4, 8 or 16 hours, thus mimicking unbuffered gastric juice. Changes in gene expression, viability and survival were determined. The bacterial load of H. pylori infected gerbils was determined with and without profound acid inhibition. Results: At pH 3.0, but not at pH 4.5 or 7.4, there was decreased expression of ~400 genes, including many cell envelope biosynthesis, cell division genes and penicillin-binding proteins. In the presence of ampicillin, viability and survival declined at pH 4.5 and 7.4 but not at pH 3.0. Profound acid inhibition of H. pylori infected gerbils increased the antral bacterial load >3 fold, showing that elevation of intragastric pH stimulated growth. Conclusions: Ampicillin is bactericidal at pH 4.5 and 7.4, but not at pH 3.0, due to decreased expression of cell envelope and division genes at pH 3.0. Therefore, at pH 3.0, the pH at the gastric surface, the bacteria are non-dividing and persist with ampicillin treatment. A more effective inhibitor of acid secretion that maintains gastric pH near neutrality for 24 hours/day should enhance the efficacy of triple therapy and of amoxicillin, even allowing dual therapy for H. pylori eradication. There were a total of three biological replicates, each containing one control (incubated at pH 7.4) and one acidic (pH 3.0) sample, whose RNA were extracted on different dates. Microarray studies performed on these six samples were done in triplicate. One of the triplicates for two of the biological control triplicates were removed from the data set due to poor hybridization

Dataset Information

Systematic review of the relationship of Helicobacter pylori infection with geographical latitude, average annual temperature and average daily sunshine.

Publications

Systematic review of the relationship of Helicobacter pylori infection with geographical latitude, average annual temperature and average daily sunshine.

Similar Datasets

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