Ontology highlight
ABSTRACT:
SUBMITTER: Garcia V
PROVIDER: S-EPMC5908532 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Garcia Victor V Glassberg Emily C EC Harpak Arbel A Feldman Marcus W MW
Journal of the Royal Society, Interface 20180301 140
Within-host adaptation of pathogens such as human immunodeficiency virus (HIV) often occurs at more than two loci. Multiple beneficial mutations may arise simultaneously on different genetic backgrounds and interfere, affecting each other's fixation trajectories. Here, we explore how these evolutionary dynamics are mirrored in multilocus linkage disequilibrium (MLD), a measure of multi-way associations between alleles. In the parameter regime corresponding to HIV, we show that deterministic earl ...[more]