Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC5910849 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20180402 16
DNA damage poses a serious threat to genome integrity and greatly affects growth and development. To maintain genome stability, all organisms have evolved elaborate DNA damage response mechanisms including activation of cell cycle checkpoints and DNA repair. Here, we show that the DNA repair protein SNI1, a subunit of the evolutionally conserved SMC5/6 complex, directly links these two processes in <i>Arabidopsis</i> SNI1 binds to the activation domains of E2F transcription factors, the key regu ...[more]